Learn About Bone Grafts
Product Image
Product Details
Autograft bone, derived locally or from a second surgery site on the patient, provides a scaffold, signaling proteins, and viable cells.1 The osteoinductivity of autograft is limited to those areas of bone which were undergoing routine remodeling.
Local autograft originates from the surgical site. Once it is removed, it may be processed through a bone mill, and then re-implanted in the surgical site. Autograft may also be taken from a second surgery site, such as the iliac crest or the medullary canal, and then implanted in the surgical site.
- Osteoconductive: Natural bone matrix facilitates cell attachment and proliferation, and vascular in-growth
- Osteoinductive: Provides natural levels of proteins that encourage mesenchymal stem cells to become osteoblasts
- Osteogenic: Provides lineage-committed bone cells, which can make bone matrix soon after implantation, and mesenchymal stem cells, which can eventually become osteoblasts
COMPARISON OF GRAFT PROPERTIES | |||
| Osteoconductive | Osteoinductive | Osteogenic | |
| Mineralized Bone Allografts |  | ||
| Demineralized Bone Matrix | | | |
| Cellular Bone Matrix | | | |
Autograft* | | | |
| Synthetics | | ||
| Recombinant Proteins | | ||
| Combination Grafts | | | |
| Xenograft | | ||
*Autograft is partially demineralized, and therefore its osteoinductivity (signals) are unenhanced compared to grafts with fully demineralized bone.
- Autograft can be used to fill a bone defect in any part of the body, including structural defects
- Autograft can provide all three necessary properties for good bone grafting; however, the quality of the autograft is dependent upon the patient’s health
- LifeNet Health offers OsteoCleanse, a cleaning and storage service, for autologous cranial flaps
- https://www.lifenethealth.org/osteocleanse/osteocleanse-storage
References
References
- Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ. Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery. J Orthop Trauma. 2019 Apr;33(4):203-213. doi: 10.1097/BOT.0000000000001420. PMID: 30633080Autograft bone, derived locally or from a second surgery site on the patient, provides a scaffold, signaling proteins, and viable cells.1 The osteoinductivity of autograft is limited to those areas of bone which were undergoing routine remodeling.