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Learn About Allografts

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Blue rings representing Synthetic grafts
Product Details


Synthetic bone substitutes provide a scaffold designed to imitate human bone. They are made from a variety of different materials, including beta tri-calcium phosphate, bioactive glass, hydroxyapatite, polyether ether ketone (PEEK), and others.1,2

Synthetic bone substitutes come in a wide variety of forms, including bone void fillers of different configurations and sizes, as well as structural grafts designed to provide support upon implantation.

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synthetic chart
  • Osteoconductive: Imitation bone matrix designed to facilitate cell attachment and proliferation, and support vascular in-growth
  • Can be less costly than natural bone
  • Many different shapes, sizes, and functional purpose are available


 Mineralized Allograftstick icon  
Demineralized Bone Matrixtick icontick icon 
Cellular Bone Matrixtick icontick icontick icon
Autograft*tick icontick icontick icon


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Recombinant Proteins tick icon 
Combination Graftstick icontick icon 
Xenografttick icon  

*Autograft is partially demineralized, and therefore its osteoinductivity (signals) are unenhanced compared to grafts with fully demineralized bone.

  • As Class II or Class III medical devices, each synthetic product will have specific indications listed in its Instructions for Use (IFU). 
  • All other use is considered off-label in contrast to allograft and autograft which can be used anywhere bone formation is needed.
  • LifeNet Health offers natural bone allografts with no synthetic components


  1. Wang W, Yeung KWK. Bone grafts and biomaterials substitutes for bone defect repair: A review. Bioactive Materials/ 2017; 2(4); 224-247. ISSN 2452-199X.
  2. Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J. Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules. 2021 May 18;26(10):3007. doi: 10.3390/molecules26103007. PMID: 34070157; PMCID: PMC8158510.